Fibroids are usual and benign tumors in uterine area that may develop as different sized single or as aggregated clusters of tumors. They mainly develop in premenopausal women. Their growth depends upon hormone called estradiol or progesterone. They can grow towards submucous (the uterine cavity) or towards subserosal (the abdominal cavity). They can also found within the intramural (uterine wall). Fibroids can be asymptomatic or linked with a various complains like pressure, menometrorrhagia, constipation, frequent urination, constipation, and pain. These symptoms are associated with number, size, and location of fibroids.
For long it is believed that fibroids that distort uterine cavity are linked with miscarriages or infertility. This link between reproductive failures and fibroids has been researched for several times. Most of these studies are affected by the similar problems like small sample size, a retrospective design and inappropriate or no controls. A meta-analysis may improve the shortcomings of studies. Moreover, few studies have addressed the advantages of several treatments in a well managed manner. To make issue more complicated, various treatment methods like radiologic, surgical and medical, options are available, however their effects would required a separate evaluation.
The Study based on results of 23 different studies and it is an update of previous review. Generally fibroids, regardless of its location, were linked with a 15 percent reduction in pregnancy rates, a 30 percent reduction in the live birth rates, and 67% increase in miscarriages rates when matched with the controls without fibroids.
These effects were especially prominent when submucous fibroids were assessed (64 percent reduction in pregnancy, 69 percent reduction in the live birth, and 67 percent increase in miscarriages). The effect of intramural fibroids was noteworthy however less prominent (22 percent reduction in live birth rates, 89 percent increase in the miscarriage rates). Actually subserous fibroids didn’t affect pregnancy outcomes at all. The analysis failed to demonstrate a steady effect on pregnancy rates as well as pregnancy outcomes.
Myomectomy was linked with the improved pregnancy outcomes when evaluated for submucosal myomas. The pregnancy rates were considerably higher after myomectomy when compared with females with fibroids left. A small number of subjects evaluated and it was found that the elimination of intramural fibroids wasn’t actually linked with any improved pregnancy results.
Although, author of Fibroids Miracle Review says, fibroids affect reproductive rates, studies are very few and weakly designed to evaluate effect of fibroids on reproduction. A cause-and-effect evaluation seems clear between reproductive failures and submucosal fibroids. Myomectomy can improve the pregnancy results. The link between lower pregnancy rates and intramural fibroids also found to be obvious.